Thursday, April 10, 2014

Clopidogrel + Aspirin


Prevention of atherosclerotic events in patients with history of symptomatic atherosclerotic diseases (ischemic stroke, myocardial infarction or acute coronary syndrome).

Dosage and Administration

 Once daily.

Contraindication and Precaution

Hypersensitivity to any of the components or NSAIDs. Active pathological bleeding such as peptic ulcer or intracranial hemorrhage or bleeding disorders T7-T10 spinal segments. With the patient receiving the injection in the horizontal position and then turned supine, the blockade spreads to T4-T7 spinal segments. It should be understood that the level of spinal anesthesia achieved with any local anesthetic can be unpredictable in
a given patient. The Effects of Anespine exceeding 4 ml have not yet been studied and such volumes can therefore not be recommended.

Contraindication & Precaution

 Spinal anesthesia should only be undertaken by clinicians with the necessary knowledge and experience. Patients with hypovolemia due to any cause can develop sudden and severe hypotension during spinal
anesthesia. It is contraindicated in patients with a known hypersensitivity to it or to any local anesthetic agent of the amide type. The following conditions preclude the use of spinal anesthesia: severe haemorrhage,
severe hypotension or shock and arrhythmias, such as complete heart block, which severely restrict cardiac output.

Side Effect

 The safety of Bupivacaine is comparable to that of other local anesthetics used for spinal anesthesia. In rare cases Bupivacaine has been associated
with allergic reactions and anaphylactic shock. Spinal anesthesia itself can cause hypotension and bradycardia due to sympathetic blockade and/or vasovagal fainting. Systemic adverse reactions are characterized by  numbness of thetongue, Lightheadedness, dizziness and
tremors, followed by convulsions and cardiovascular disorders.

Use in Pregnancy & Lactation

Bupivacaine enters the mother’s milk but in such small quantities that there is generally no risk of affecting the child at therapeutic dose levels. There is no may be encountered during Losartan potassium treatment.

Use in Pregnancy & Lactation

 Losartan potassium should not be used in pregnancy and if pregnancy is detected Losartan potassium should be discontinued as soon as possible. Losartan potassium should not be used in lactating mother.

Drug Interaction

 No drug interaction of clinical significance has been identified.

Preparation:  25 mg, 50 mg & 100 mg Tablet.


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