Indication
•
All forms of amoebiasis (intestinal and extra-intestinal disease including
liver abscess and that of symptomless cyst passers)
•
Trichomoniasis
•
Giardiasis
•
Bacterial vaginosis
•
Acute ulcerative gingivitis
•
Anaerobic infections including
septicaemia,
bacteraemia, peritonitis,
brain
abscess, necrotising pneumonia,
osteomyelitis,
puerperal sepsis, pelvic
abscess,
pelvic cellulitis etc.
•
Anaerobically-infected leg ulcers and pressure sores
•
Acute dental infections (e.g. acute pericoronitis and acute apical infections)
•
Surgical prophylaxis (prevention of postoperative infections due to anaerobic bacteria,
particularly species of bacteroides and anaerobic streptococci
•
Chronic symptomatic peptic ulcer disease (as an agent of triple therapy to
eradicate
H.
pylori-the most important aetiological factor
of peptic ulcer)
- Dosage and Administration
|
Indication
|
Duration of
dosage
in days
|
Adults and children over10 years
|
Children
|
|||||
|
Trichomoniasis
|
7
|
200 mg t.i.d or 400 mg b.i.d
|
100 mg t.i.d
|
100 mg t.i.d
|
50 mg t.i.d
|
|||
|
2
|
800
mg in the morning and 1.2 gm at night
|
|
|
|
||||
|
1
|
2.0 gm as a single dose
|
|
|
|
||||
|
Invasive intestinal
amoebiasis
|
5
|
800 mg t.i.d.
|
400 mg
t.i.d.
|
200 mg
q.i.d.
|
200 mg
t.i.d.
|
|||
|
Extra intestinal
amoebiasis (including
liver abscess) and
symptomless amoebic
cyst
passers
|
5-10
|
400 -800 mg
t.i.d.
|
200 -400 mg
t.i.d
|
100-200 mg
q.i.d
|
100-200 mg
q.i.d
|
|||
|
Giardiasis
|
3
|
2.0 gm once
daily 1.0 gm
once daily
600-800 mg
500 mg
|
1.0 gm once
daily
|
6 0 0 - 8 0 0
mg once
daily
|
500 mg once
daily
|
|||
|
Acute ulcerative
gingivitis
|
3
|
200 mg t.i.d.
mg t.i.d.
|
100 mg
|
100 mg
b.i.d.
|
50 mg
t.i.d.
|
|||
|
Acute dental
infections
|
3-7
|
200 mg t.i.d.
|
|
|
|
|||
|
Bacterial vaginosis
|
5-7
|
400–500 mg
twice daily
|
|
|
|
|||
|
1
|
2.0 gm as a
single dose
|
|||||||
|
Leg ulcers and pressure
sores
|
7
|
400 mg t.i.d.
|
|
|
|
|||
|
Anaerobic infections
|
7
|
Either 400
mg every 8
hours
or 500 mg every
8 hours
|
7.5 mg/kg
t.i.d.
|
7.5 mg/kg
t.i.d
|
7.5 mg/kg
t.i.d
|
|||
|
Surgical prophylaxis
|
|
400–500 mg
2 hours
b e f o r e
surgery;
up to 3 further
doses of
400–500 mg
may be given
every 8
hours for
h i g h - r i s k
procedures
|
7.5 mg/kg
t.i.d.
|
7.5 mg/kg
t.i.d.
|
7.5 mg/kg
t.i.d.
|
|||
Side Effect
Metalic taste, furred tongue, nausea, vomiting,
diarrhoea, drowsiness, rashes and mild reversible leucopenia may be
observed during treatment.
Drug
Interaction
Metronidazole interacts with
warfarin, nicoumalone, phenytoin, phenobarbitone, fluorouracil,
disulfiram, lithium, cimetidine etc.
A Use in Pregnancy & Lactation
Not
recommended during first & later trimesters. Breast
feeding should be delayed until 48 hours after discontinuing
metronidazole in the mother.
Presentation:
400
mg Tablet, 500 mg Tablet & 200 mg/5ml Suspension.
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