Efavirenz

Indication

 In combination with other antiretroviral agents is indicated for the treatment of HIV infection.

Dosage and Administration

 Adults : 600 mg orally, once daily, in combination with a protease inhibitor and/or nucleoside analogue reverse transcriptase inhibitors (NRTIs).

Pediatric Patients  

 Weighing greater than 40 kg is 600 mg, once daily.

Body weight (kg) Adiva: Dose (mg)

10 to <15 200

15 to <20 250

20 to <25 300

25 to <32.5 350

32.5 to <40 400

>40 600

(2.5 ml of syrup) 3 to 4 times a day. In motion sickness: Adults : 25 to 50 mg 3 to 4 times a day. Children (above 9.1 kg): 12.5 to 25 mg 3 to 4 times a day (5mg/ kg/ 24 hours). In parkinsonism: Adults: 25 to 50 mg 3 to 4 times a day. Children (above 9.1 kg) : 12.5 to 25 mg 3 to 4 times a day (5mg/ kg/ 24 hours). In insomnia: Adults and children over 12 years of old : A dose of 20 to 50 mg is used as hypnotic in insomnia. In cough & cold: Adults: 25 mg every 4 hrs. Not to exceed 150 mg in 24 hours. Children (6 to 12 years) : 12.5 mg every 4 hours. Not to exceed 75 mg in 24 hours. Children (2 to 6 years): 6.25 mg every 4 hours.

Contraindication and Precaution

Contraindicated for the premature or newborn infants. Any patients in whom drowsiness is undesirable e.g. drivers,

machine operators. Patients with known hypersensitivity to Diphenhydramine or any components of the product. Patients should be cautioned not to operate vehicles or hazardous machinery until their response to the drug has been determined.

Drug Interaction

Antituberculous agent, para-aminosalicylic acid (PAS), alcohol, other CNS depressants (hypnotics, sedatives, tranquilizers, etc), MAO inhibitors.

Side Effect

Side Effects include drowsiness, dizziness, dryness of mouth, blurred vision, nausea and vomiting.

Uses in Pregnancy & Lactation

 Should be used in pregnancy only if clearly needed. Use in lactating mother is not recommended.