Bromazepam

Description :

Bromazepam is a global anxiolytic with smooth and supprior efficacy. It is one of the benzodiazepines having no side-effects like other benzodiazepines. It effectively manages anxiety and also removes anxiety related various physiological  problems.

Mode of action: 

Bromazepam binds with the specific site on the GABA receptor/chloride channel complex and potentiates the effect of GABA, an important inhibitory transmitter in the CNS which acts by opening chloride ion channels into cells.

Pharmacokinetics:

Peak plasma concentration of Bromazepam is achieved within two hours after oral administration. The absolute bioavailability of the unchanged substance is 60%. On an average 70% of Bromazepam is metabolized in the liver. Bromazepam has an elimination half-life around 20 hours, but the half-life may be longer in elderly subjects. The metabolites are excreted in the urine mainly in conjugated form.

Composition:

Bromazepam tablet: Each tablet contains Bromazepam BP 3 mg

                                                                                         

Indications:

Emotional disturbances: Anxiety and tension states, as adjuvant therapy for anxiety in depressed patients, nervous, tension, restlessness, anxiety and tension related insommia. As an adjuvant to the treatment of an underlying disease responsible for functional or psychosomatic impairments of various organs caused or exacerbated by anxiety and tension.

Cardiovascular and respiratory systems: Pseudo angina pectoris, precordial anxiety, tachycardia, emotiogenic hypertension, dyspnea and hyperventilation; Gastrointestinal tract: irrible bowel syndrome, ulcerative colitis, epigastric pain, spasm, meteorism and diarrhea.

Urogential tract: Irritable bladder, urinary frequency, dysmenorrhoea; Other psychosomatic disturbances: Psychogenic headache, psychogenic dermatoses.

Bromazepam is also suitable for treatment  of anxiety and tension states due to chronic organic diseases and as an adjuvant to psychotherapy in psychoneuroses, acute alcohol withdrawal, adjunct for the relief of muscle spasm.

Dosage and Administration :

1.50mg to 12 mg three times daily according to condition or patient response and  side-effect profile.

Average outpatient dosage: 1.5 mg to 3 mg three times daily.

Severe cases: 6 mg to 12 mg two to three times daily.

Contraindications:

Bromazepam should not be used in case of hypersensitivity of benzodiazepines, respiratory depression, severe hepatic impairment, myasthenia gravis and infant.

Side Effects:

Drowsiness, lightheadedness in the next day; confusion, ataxia and ammesia may occur.

Use in pregnancy and lactation:

The administration of Bromazepam is rarely justified in woman of childbearing potential. Bromazepam should be  avoided during breast-feeding.

Precautions:

Bromazepam should be used cautiously in respiratory diseases, muscle weakness and history of alcohol or drug abuse.

Drug Interactions:

Phenothiazines, barbiturates, MAO inhibitors and psychoactive drugs may potentiate the action of Bromazepam and should not usually be given concurrently.

Overdosage:

Manifestations of overdoage include somnolence, confusion and respiratory and cardiovascular depression with coma in severe cases. 

Storage:

Store in a cool and dry place, protected from light and children’s.