Nitroglycerin

Indication:

Indicated for the acute relief of an attack or acute prophylaxis of angina pectoris due to coronary artery disease.

Dosage and Administration:

One tablet should be dissolved under the tongue at the first sign of an acute anginal attack. The dose may be repeated approximately every five minutes, until relief is obtained. If the pain persists after a total of 3 tablets in a 15-minute period, prompt medical attention is recommended. Injection: The usual dose range is 10 -200 mcg/min. Dose up to 400 mcg/min may be required during some surgical procedures.

Contraindication & Precaution:

Contraindicated in patients with early myocardial infarction, severe anemia, increased intracranial pressure and those with a known hypersensitivity to Nitroglycerin. Also contraindicated in patients who are using sildenafil citrate since sildenafil citrate has been shown to potentiate the hypotensive Effects of organic nitrates. Only the smallest dose required for Effective control of the acute angina attack should be used. Excessive use may lead to the development of tolerance. This drug should be used with caution in patients who may be volume-depleted or are already hypotensive.

Drug Interaction:

Antihypertensive drugs, beta-adrenergic blockers, phenothiazines, calcium channel blockers, alcohol, aspirin, ergotamine and related drugs.

Side Effect:

Headache which may be severe and persistent may occur immediately after use. Vertigo, dizziness, weakness, palpitation and other manifestations of postural hypotension may developoccasionally.

Use in Pregnancy & Lactation:

Should be given to a pregnant woman only if clearly needed. It is not known whethernitroglycerin is excreted in human milk.

Preparation:

0.5 mg Sublingual Tablet, 5 mg/ ml IV Injection, 2.6 mg SR (Sustained Release) Tablet.