Indication
Metronidazole
500 IV is indicated in the prophylaxis
and treatment of infections in which anaerobic bacteria have been identified.
It is indicated in:
1.The
prevention of postoperative infections due to anaerobic bacteria
2.The
treatment of septicemia, bacteraemia, peritonitis, brain abscess, necrotizing pneumonia,
osteomyelitis, puerperal sepsis, pelvic abscess, pelvic cellulites, and post operative
wound infections from which pathogenic anaerobes have been isolated.
Dosage
& Administration
Metronidazole
500 IV should be infused intravenously
at an
approximate
rate of 5 ml/min. Oral medication should be substituted as soon as feasible. Treatment
for 7 days should be satisfactory for most patients, but the physician might decide
to prolong treatment.
For
bacterial infections:
Adults:
500 mg (100 ml) 8 hourly.
Children: 7.5 mg/kg
(1.5 ml/kg) 8 hourly.
For
treatment before and during surgery:
Adults:
500 mg (100 ml) shortly before operation, repeated 8 hourly
Children:
7.5 mg/kg (1.5 ml/kg) 8 hourly.
Side
Effect
Pain,
tenderness, redness or swelling over vein in which the medicine is
given.
Other side Effects are unsteadiness, fever or chills, sore throat, headache, numbness,
tingling pain or weakness in the hands or feet, pain, seizures, skin itching,
unusual tiredness or weakness, vaginal irritation or discharge.
Drug
Interaction
Metronidazole
shows drug interaction with the following:
alcohol
or alcohol-containing beverages, barbiturates, carbamazepin, cimetidine, disulfiram,
fluorouracil, lithium, methadone, phenytoin, warfarin etc.
Use
in pregnancy & lactation
Studies
have not been done in humans. Metronidazole has not been shown to cause birth
defects in animal studies; however, use is not recommended during the first
trimester of pregnancy. Use is not recommended in nursing mothers since metronidazole
passes into the breast milk.
Precaution
Metronodazole
should be given with caution in the following conditions- anemia or other blood
disorders, liver disease, disease of nervous system, seizures etc.
Preparation
100 ml
solution of Metronidazole for intravenous infusion.
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